用丹贝异黄酮提取物对携S 180肿瘤的BALB/C小鼠作用 ,结果丹贝异黄酮提取物高剂量时有 30 9%的抑瘤率 ,并能显著提高荷瘤小鼠的胞腺指数、脾指数和巨噬细胞的吞噬作用。以分离纯化的大豆和丹贝异黄酮的 5个单体染料木素糖苷、大豆苷元糖苷、黄豆黄素苷元、染料木素苷元、大豆苷元 (genistin、daidzin、glycitein、genistein、daidzein)分别作用于乳腺癌MCF 7细胞株、子宫癌HeLa细胞株和卵巢癌HO 8910细胞株 ,研究各单体对各种癌细胞株的抑制率和IC50值。结果显示 ,染料木素在 10 -4mol·L-1时对 3株癌细胞均有较高的抑制率 ,大豆苷元在 10 -4mol·L-1时对卵巢癌HO 8910细胞株有较强的抑制效果。丹贝异黄酮比大豆异黄酮有更强的抑制肿瘤的作用 ,其中染料木素有更广泛、更强的活性 ,而糖苷几乎没有抑制肿瘤的作用 The effect of Danbei isoflavone extract on S180 tumor-bearing BALB / C mice resulted in a 30.9% inhibition rate of Danbei isoflavone extract at high doses and significantly increased the cytoplasm of tumor-bearing mice Index, spleen index and macrophage phagocytosis. In order to isolate and purify the five monomer genistein, daidzein, daidzein, daidzin, daidzein, daidzin, daidzin, ), Respectively, on breast cancer MCF 7 cell line, uterine cancer HeLa cell line and ovarian cancer cell line HO 8910 to study the inhibitory rate and IC50 value of each monomer on various cancer cell lines. The results showed that genistein had a higher inhibitory rate on all three cancer cells when the concentration of genistein was 10 -4 mol·L-1. The daidzein at 10 -4 mol·L-1 had a stronger inhibitory effect on ovarian cancer cell line HO 8910 Inhibitory effect. Danbei isoflavones have a stronger inhibitory effect on tumor than soy isoflavones, of which genistein has a broader and stronger activity, while glycosides have almost no effect on tumor inhibition