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目的 探讨CD2 8在多发性硬化 (MS)患者CD8+ 淋巴细胞的表达水平。方法 流式细胞仪测定 16例复发期MS患者和 2 0例对照组外周血淋巴细胞CD2 8+ 、CD8+ CD2 8- 和CD8+ CD2 8+ 的百分率。结果 复发期MS患者淋巴细胞CD8+CD2 8- 百分率低于对照组 ,CD2 8+ 和CD8+ CD2 8+ 的百分率与对照组无明显差异 ;甲基强的松龙治疗对CD2 8+ 、CD8+ CD2 8- 和CD8+ CD2 8+ 的百分率无影响。结论 参与MS的发病的CD8细胞是CD8+ CD2 8- 细胞
Objective To investigate the expression of CD28 on CD8 + lymphocytes in patients with multiple sclerosis (MS). Methods Flow cytometry was used to determine the percentage of CD8 +, CD8 +, CD8-8 and CD8 + CD28 in 16 patients with relapsed MS and 20 controls. Results The percentage of CD8 + CD28 in lymphocytes was lower in MS patients at relapse than that in control group. There was no significant difference between CD8 +, CD8 + and CD8 + CD8 + - No effect on the percentage of CD8 + CD2 8+. Conclusions CD8 cells involved in the pathogenesis of MS are CD8 + CD2 8- cells