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目的观察厄贝沙坦氢氯噻嗪早期联合美托洛尔治疗老年心力衰竭的疗效。方法选取该院老年心力衰竭患者65例,随机分为观察组33例和对照组32例,观察组给予厄贝沙坦氢氯噻嗪早期联合美托洛尔治疗,对照组给予美托洛尔治疗。比较2组临床疗效和治疗前后B型利钠肽(BNP)、左室射血分数(LVEF)水平。结果观察组治疗总有效率为87.9%明显高于对照组的59.4%,差异具有统计学意义(P<0.05)。2组患者治疗前BNP、LVEF水平均无明显差异(P>0.05),治疗后2组患者BNP水平均降低,LVEF水平均升高,且观察组变化幅度大于对照组,差异均有统计学意义(P<0.05)。结论厄贝沙坦氢氯噻嗪早期联合美托洛尔治疗老年心力衰竭疗效好,应用价值高,值得在临床实践中推广应用。
Objective To observe the efficacy of irbesartan and hydrochlorothiazide combined with metoprolol in the treatment of elderly patients with heart failure. Methods Sixty-five elderly patients with heart failure were selected and randomly divided into observation group (33 cases) and control group (32 cases). The observation group was treated with irbesartan hydrochlorothiazide combined with metoprolol and the control group metoprolol. The clinical efficacy and the levels of B-type natriuretic peptide (BNP) and left ventricular ejection fraction (LVEF) before and after treatment were compared between the two groups. Results The total effective rate of observation group was 87.9%, which was significantly higher than that of control group (59.4%), the difference was statistically significant (P <0.05). There was no significant difference in BNP and LVEF levels between the two groups before treatment (P> 0.05). After treatment, the levels of BNP, LVEF and LVEF in both groups were significantly lower than those in the control group (P <0.05). Conclusion Irbesartan hydrochlorothiazide combined with metoprolol early treatment of elderly patients with heart failure has good curative effect and high application value. It is worth to be popularized in clinical practice.