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c AMP反应元件结合蛋白(c AMP-responsive element binding protein,CREB)作为转录因子,促进启动子中具有c AMP反应元件(c AMP response element,CRE)的基因转录。近年的研究显示,CREB转录共激活因子(CREB-regulated transcription coactivator,CRTC;又名transducer of regulated CREB,TORC)家族可以显著增强CREB靶基因的转录。CRTC家族有3个成员(CRTC1~3),其中CRTC1在脑组织中高表达。一些研究表明CRTC1在神经元树突生长发育、长时程突触可塑性、记忆巩固和再巩固等过程中发挥重要作用;且在神经退行性相关疾病等发病过程中出现表达或活性异常。本文主要针对CRTC1表达或活性异常在神经退行性相关疾病发病过程中的作用及分子机制做一综述。
c AMP-responsive element binding protein (CREB) as a transcription factor to promote transcription of c AMP response element (CRE) in the promoter. Recent studies have shown that the CREB transcriptional coactivator (CRTC; also known as transducer of regulated CREB, TORC) family can significantly enhance the transcription of CREB target gene. CRTC family has 3 members (CRTC1 ~ 3), of which CRTC1 is highly expressed in brain tissue. Some studies have shown that CRTC1 plays an important role in the process of dendritic growth and development, long-term synaptic plasticity, memory consolidation and re-consolidation in neurons. In addition, CRTC1 has abnormal expression or activity in the pathogenesis of neurodegenerative diseases. This article focuses on the role of CRTC1 expression or activity abnormalities in the pathogenesis of neurodegenerative diseases and molecular mechanisms are reviewed.