γ-重链病涉及B淋巴细胞、浆细胞、淋巴浆细胞的单个无性系的增殖,这些细胞分泌过多的游离重链多肽碎片,在血清或尿中能被检出。该病少见,其病因还不清楚,发病年龄9～87岁(中位数61岁)。γ-重链病的临床表现多种多样,有主诉虚弱或体重减轻者,可能有局部及全身性淋巴腺病,多累及咽淋巴环。常因舌部灼痛、声嘶、腭部水肿、上呼吸及消化道粘膜病变、腮腺肿胀、甲状腺新生物、淋巴腺病、反复感染而到咽喉科会诊。本文报道了一个58岁男性病例,因逐渐出现吞咽困难、声嘶、口腔烧灼感就诊。检查发现于上呼 Gamma-heavy chain disease involves proliferation of individual clones of B lymphocytes, plasma cells, and lymphocyte plasma cells that secrete excess fragments of free heavy chain polypeptides that can be detected in serum or urine. The disease is rare, the etiology is not clear, the age of onset of 9 to 87 years (median 61 years). Clinical manifestations of γ-heavy chain disease varied, there are complaints of weakness or weight loss, there may be local and systemic lymphatic disease, involving multiple pharyngeal lymph nodes. Often due to tongue burning, hoarseness, palate edema, upper respiratory tract and gastrointestinal mucosal lesions, parotid swelling, thyroid neoplasms, lymphatic disease, recurrent infection to the throat consultation. This article reports a 58-year-old man with a history of dysphagia, hoarseness, and mouth-burning. Check found on the call