目的:探讨精神分裂症不同症状分型之间突触素及波形蛋白水平的差异，及其与精神病性症状之间的关系。方法:选取100例精神分裂症患者和100例健康被试(对照组)。使用阳性和阴性症状量表(positive and negative syndrome scale，PANSS)对精神分裂症患者进行评估，分为阳性症状为主的病例组(阳性组，n n＝59)、以阴性症状为主的病例组(阴性组，n n＝41)。采用酶联免疫吸附法(Elisa法)测定所有被试的血清突触素及波形蛋白水平。采用SPSS 17.0独立样本n t检验比较各组间血清突触素和波形蛋白水平的差异，Pearson相关分析精神分裂症患者阳性和阴性症状与血清突触素、波形蛋白水平的相关性。n 结果:阳性组：治疗后突触素[(80.34±9.94)μg/L]低于治疗前[(102.89±12.03)μg/L]，治疗后波形蛋白[(10.81±1.98)μg/L]低于治疗前[(13.96±2.10)μg/L]，均差异具有统计学意义(均n P<0.01)。阴性组：治疗后突触素[(80.42±10.61)μg/L]低于治疗前[(102.98±11.04)μg/L]；治疗后波形蛋白[(11.18±1.74)μg/L]低于治疗前[(14.14±1.82)μg/L]；差异具有统计学意义(n P<0.01)；阳性组及阴性组治疗前后突触素均高于对照组[(64.29±11.26)μg/L]；阳性组及阴性组治疗前后波形蛋白均高于对照组[(8.33±1.62)μg/L]；均差异具有统计学意义(均n P<0.01)。所有患者治疗后PANSS总分及各分量表分均较治疗前明显下降，差异有统计学意义(n P<0.05)。Pearson相关性分析提示，阳性组血清突触素水平与阳性量表分呈正相关(n r＝0.650，n P<0.01)；阴性组血清波形蛋白水平与阴性量表分正相关(n r＝0.629，n P<0.01)。n 结论:阳性症状为主与阴性症状为主的精神分裂症可能存在不同的病理学机制。“,”Objective:To investigate the difference and relationship between synaptophysin, vimentin in positive or negative schizophrenia.Methods:Fifty-nine patients with schizophrenia mainly presented positive syndrome(positive case group), 41 patients with schizophrenia mainly presented negative syndrome(negative case group), 100 individuals without schizophrenia were enrolled.Patients with schizophrenia were assessed with positive and negative symptom scale (PANSS), then the patients were divided into positive symptom group (positive group, n n=59) and negative symptom group (negative group, n n=41). The serum levels of synaptophysin and vimentin were measured by enzyme-linked immunosorbent assay (Elisa). The levels of serum synaptophysin and vimentin were compared among the groups by independent n t test.The correlation between positive and negative symptoms and serum levels of synaptophysin and vimentin were analyzed by Pearson correlation analysis.n Results:In the positive case group: the synaptophysin level after treatment ((80.34±9.94)μg/L)was significantly lower than that before treatment ((102.89±12.03)μg/L). The vimentin level after treatment ((10.81±1.98)μg/L)was significantly lower than that before treatment((13.96±2.10)μg/L). The differences were statistically significant(bothn P<0.01). In the negative case group: the synaptophysin level after treatment ((80.42±10.61)μg/L) was significantly lower than that before treatment((102.98±11.04)μg/L). The vimentin level after treatment ((11.18±1.74)μg/L)was significantly lower than that before treatment((14.14±1.82)μg/L). The differences were statistically significant(bothn P<0.01). The synaptophysin levels in the positive case group and the negative case group were significantly higher than those in the control group((64.29±11.26)μg/L). The vimentin levels in the positive case group and the negative case group were significantly higher than those in the control group((8.33±1.62)μg/L). The differences were statistically significant(alln P<0.01). The PANSS score of the positive and negative case group were significantly decreased after treatment compared with before treatment, the differences were statistically significant(n P<0.05). Pearson correlation analysis suggested that synaptophysin was positively correlated with positive scale score in positive case group(n r=0.650, n P<0.01). Vimentin was positively correlated with negative scale score in negative case group(n r=0.629, n P<0.01).n Conclusion:There may be different pathological mechanisms in schizophrenia with positive and negative symptoms.