论文部分内容阅读
Objective To investigate the effect of intra-operative intravenous fluids on post-operative hemodynamic stability.Methods We performed a retrospective cohort study of 98 preterm infants who underwent a patent ductus arteriosus(PDA) ligation in one NICU between 2001 and 2007.The primary outcome was the need for cardiotropic support within 24 hrs of ligation.Results Twenty-seven infants(28%) required post-operative cardiotropic support.The amount of intra-operative fluids varied between 0 and 50.4 mL/kg(median:10.2 mL/kg).No intra-operative fluid was recorded in 26 patients.Fluids were not associated with the need for post-operative cardiotropic support(P=0.10).Using a multivariate logistic regression model,age at ligation,weight at ligation and pre-operative FiO2 were significant predictors of post-operative cardiotropic support.Conclusions Intra-operative fluids do not appear to be associated with the need for post-operative cardiotropic support.A prospective cohort study may help identify modifiable risk factors and improve outcomes in this population.
Objective To investigate the effect of intra-operative intravenous fluids on post-operative hemodynamic stability. Methods We performed a retrospective cohort study of 98 preterm infants who underwent a patent ductus arteriosus (PDA) ligation in one NICU between 2001 and 2007. was the need for cardiotropic support within 24 hrs of ligation. Results Twenty-seven infants (28%) required post-operative cardiotropic support. The amount of intra-operative fluids varied between 0 and 50.4 mL / kg (median: 10.2 mL / kg ) .No intra-operative fluid was recorded in 26 patients. Fluids were not associated with the need for post-operative cardiotropic support (P = 0.10). Using a multivariate logistic regression model, age at ligation, weight at ligation and pre-operative FiO2 were significant predictors of post-operative cardiotropic support. Conclusions Intra-operative fluids do not appear to be associated with the need for post-operative cardiotropic support. A prospective cohort study may help iden tify modifiable risk factors and improve outcomes in this population.