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我们对７６例急性白血病（ＡＬ）患儿进行了骨髓细胞姐妹染色单体交换（ＳＣＥ）频率的动态观察和分析。结果显示：初发组、部分缓解（ＰＲ）组ＳＣＥ频率增高，与完全缓解（ＣＲ）组比较均有非常显著的差异（Ｐ＜０．０１）。与对照组相比，ＣＲ组ＳＣＥ频率仍高干对照组（Ｐ＜０．０５）。持续完全缓解３年以上者ＳＣＥ频率与对照组比较无显著差异（Ｐ＞０．０５）。表明：ＡＬ患儿治疗前骨髓细胞的ＳＣＥ水平损伤严重；ＣＲ时其损伤仍未完全修复，随着病情进一步好转，ＳＣＥ频率亦趋于正常。无标记型急性淋巴细胞白血病（ＮｕＬＬ－ＡＬＬ）患儿达ＣＲ时，ＳＣＥ频率仍高于普通型急性淋巴细胞白血病（Ｐ＜０．０５），表明不同类型的ＡＬ，ＤＮＡ损伤程度和恢复速度亦不同。
We performed a dynamic observation and analysis of the frequency of sister chromatid exchange (SCE) in bone marrow cells in 76 children with acute leukemia (AL). The results showed that the frequency of SCE increased in primary and partial remission (PR) groups, but significantly different from that in complete remission (CR) group (P <0.01). Compared with the control group, the frequency of SCE in CR group was still higher than that in control group (P <0.05). There was no significant difference in SCE frequency between patients with persistent complete remission for more than 3 years and controls (P> 0.05). The results showed that the SCE level of AL children was severely damaged before treatment. The injury of CR was not completely repaired at the time of CR. The frequency of SCE tended to be normal as the condition improved further. The frequency of SCE was still higher in patients with unlabeled acute lymphoblastic leukemia (NuLL-ALL) at CR than that of common acute lymphoblastic leukemia (P <0.05), indicating that different types of AL, DNA damage and recovery rate different.