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目的探讨系统性红斑狼疮患者男女临床特点及预后。方法对228例系统性红斑狼疮住院患者进行回顾性分析。结果患者男25例,女203例,男女比例1:8.12,平均发病年龄(32.72±13.49)岁(6~71岁),平均病程(2.33±2.82)年(20d~10年);男性组肾脏损害、口腔溃疡、神经系统损害、血小板减少、抗Sm抗体阳性较女性组多见(P<0.05),而女性组则以蝶形红斑、关节受累、雷诺现象、抗SSA阳性较多见(P<0.05);经治疗女性组好转率(83.74%)较男性组(60.00%)高(P<0.05),死亡率(5.42%)则较男性组(16.00%)低(P<0.05)。结论 SLE患者男女临床表现、实验室检查及预后有一定差别,与女性相比,男性内脏损害发生率较高且预后较差,临床应引起重视。
Objective To investigate the clinical characteristics and prognosis of patients with systemic lupus erythematosus. Methods 228 cases of systemic lupus erythematosus hospitalized patients were retrospectively analyzed. Results There were 25 males and 203 females, with a ratio of 1: 8.12 between men and women. The mean age at onset (32.72 ± 13.49) years (range, 6 to 71 years) and average duration (2.33 ± 2.82) years (20 days to 10 years) (P <0.05), while the female group had butterfly erythema, joint involvement, Raynaud’s phenomenon, and anti-SSA positive (P <0.05), while the positive rate of anti-Sm antibody (P <0.05). The improvement rate of the treated women (83.74%) was higher than that of the male patients (60.00%) (P <0.05) and the mortality rate was 5.42% (16.00%) lower than that of the male patients (P <0.05). Conclusions The clinical manifestations, laboratory tests and prognosis of SLE patients are different. Compared with women, the incidence of male visceral injuries is higher and the prognosis is poor, which should be paid more attention to in clinic.