目的:观察异常黑胆质载体动物模型实验动物的支配器官形态学改变,探讨异常黑胆质证的病理解剖学基础。方法:选择健康ICR雄性小鼠30只,分为模型组和正常对照组,每组15只。各组造模后眼球放血处死实验动物,并迅速取出支配器官脑(下丘脑)、心脏、肝脏,采用HE染色,光学显微镜下进行组织学观察,观察和比较2组实验动物支配器官形态学改变。结果:与正常对照组相比,模型组小鼠支配器官组织有明显的形态学改变。模型组下丘脑星形胶质细胞肿胀,间质血管中、重度扩张。心肌脂肪浸润,间质血管扩张。肝脏肝细胞再生程度明显,存在点状坏死、间质炎性细胞浸润。结论:机体支配器官的形态学改变可能是异常黑胆质产生的部分病理学基础。 OBJECTIVE: To observe the morphological changes of the dominant organ in experimental animals of abnormal savda carrier animal model and to explore the pathological anatomy of abnormal savda syndrome. Methods: Thirty healthy ICR male mice were divided into model group and normal control group, 15 in each group. The rats in each group were exsanguinated and the animals were sacrificed by exsanguination. The brain (hypothalamus), heart and liver of the dominant organs were rapidly removed. The cells were stained with HE and observed under a light microscope. Morphological changes of the two organs were observed and compared. . Results: Compared with the normal control group, the mouse model group had obvious morphological changes in the dominant organ tissues. Model group hypothalamus astrocytes swelling, interstitial blood vessels, severe expansion. Myocardial fat infiltration, interstitial vascular dilatation. Hepatic liver cell regeneration is obvious, there is punctate necrosis, interstitial inflammatory cell infiltration. CONCLUSION: Morphological changes of the body’s dominant organs may be part of the pathological basis for the abnormal savda.