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最近,N.Sunde等用X射线损伤新生鼠双侧海马区域,随后将另一新生鼠的正常齿状回组织移植入受损伤鼠单侧海马区域(另一侧作为对照)。发现:在非胆碱能、非单胺能神经系统,与胆碱能、单胺能系统一样,移植物和宿主神经元能够建立相互联系,并且移植物可恢复宿主已被破坏的神经联系。80%以上的齿状回颗粒细胞在出生以后形成。出生后,X射线照射几乎能选择性地使颗粒细胞数减少到正常的15%,残存的颗粒细胞传入纤维形成散乱的扁平状突起伸向CA3区维体细胞。同时苔藓纤维突起明显减少。这种X射线照射模型在许多方面与自然发生的神经细胞恶性改变及早期退行性疾病相同。将
More recently, N. Sunde et al. Injured neonatal bilateral hippocampal regions with x-rays, followed by normal dentate gyrations of another neonatal rat into the unilateral hippocampal region of injured rats (control on the other side). Found that in non-cholinergic, nonmonoaminergic systems, as with the cholinergic and monoaminergic systems, the graft and host neurons are able to establish an interconnection and that the graft can restore the host’s collapsed neural connections. More than 80% of dentate gyrus granulocytes are formed after birth. After birth, X-ray irradiation almost can selectively reduce the number of granulocytes to 15% of the normal number. The remaining granulosa cells are introduced into the fibers to form scattered flat protrusions extending to the CA3 zone astigmatism cells. At the same time moss fiber protrusions significantly reduced. This X-ray irradiation model is in many ways the same as naturally occurring malignant changes of nerve cells and early degenerative diseases. will