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目的:了解钙拮抗剂的不良反应情况。方法:检索1992～1999年7月《中国药学文摘》药物不良反应项下收载的国内医药期刊30种,文献共计113篇,对7种常用钙拮抗剂的166例不良反应原始资料进行记载、统计分析。结果:166例药物不良反应中硝苯地平62例(37.35％),占第一位,氟桂利嗪51例(30.72％),占第二位,尼莫地平20例(12.05％)占第三位;主要不良反应的发生率依次为中枢神经系统48例(28.92％),心血管系统26例(15.66％),皮肤反应21例(12.65％),局部水肿18例(10.84％)。除2例死亡外,其余164例经停药对症治疗均痊愈。结论:166例患者中50岁以上老年人112例(67.5％),多患心脑血管疾病,对常规剂量的钙拮抗剂反应敏感,应注意调整用药剂量和观察患者的临床表现,以确保用药安全。
Objective: To understand the adverse effects of calcium antagonists. Methods: Thirty kinds of domestic journals were collected under adverse drug reactions of Chinese Medical Abstracts from 1992 to July 1999. The total number of literatures was 113. A total of 166 ADR data were collected from 7 commonly used calcium antagonists. Statistical Analysis. Results: Sixty-two patients (n = 37) had nifedipine 62 cases (37.35%), and flunarizine 51 (30.72%) accounted for the second place. Nimodipine 20 (12.05%) accounted for The incidences of major adverse reactions were as follows: central nervous system in 48 cases (28.92%), cardiovascular system in 26 cases (15.66%), skin reaction in 21 cases (12.65%) and local edema in 18 cases (10.84%). In addition to 2 cases of death, the remaining 164 cases were cured by symptomatic treatment were cured. Conclusions: Of the 166 patients, 112 (67.5%) older than 50 years old had cardiovascular disease. They were sensitive to conventional doses of calcium antagonists. Safety.