[Objective] To optimize the extraction process of polysaccharide extracted with ultrasonic-microwave synergetic extraction from Hippophae fhamnoides L..[Method] By employing both the single factor test and the orthogonal test,the optimal parameters of ultrasonic-microwave synergetic extraction for the extraction of polysaccharide from Hippophae fhamnoides L.were confirmed,and the extraction efficiency was comparatively studied with that of water extraction,microwave extraction and ultrasonic extraction.[Result] The optimum extraction processes of ultrasonic-microwave synergetic extraction were as follows:180 s of extraction duration,450 W of extraction power and 1:30 of solid-liquid ratio(W/V).The yield of polysaccharide extracted from Hippophae fhamnoides L.under the optimum conditions reached 22.50 mg/g.[Conclusion] The ultrasonic-microwave synergistic extraction for the extraction of polysaccharide from Hippophae fhamnoides L.was superior to water extraction,microwave extraction and ultrasonic extraction. [Objective] To optimize the extraction process of polysaccharide extracted with ultrasonic-microwave synergetic extraction from Hippophae fhamnoides L .. [Method] By employing both the single factor test and the orthogonal test, the optimal parameters of ultrasonic-microwave synergetic extraction for the extraction of polysaccharide from Hippophae fhamnoides L. were confirmed, and the extraction efficiency was comparatively studied with that of water extraction, microwave extraction and ultrasonic extraction. [Result] The optimum extraction processes of ultrasonic-microwave synergetic extraction were as follows: 180 s of extraction duration, 450 W of extraction power and 1:30 of solid-liquid ratio (W / V). The yield of polysaccharide extracted from Hippophae fhamnoides L.under the optimum conditions reached 22.50 mg / g. [Conclusion] The ultrasonic-microwave synergistic extraction for the extraction of polysaccharide from Hippophae fhamnoides L.was superior to water extraction, microwave extraction and ultrasonic extraction.