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目的:探讨肺结核患者治疗失败的相关危险因素,为提高治疗效果提供依据。方法:将确诊的895例肺结核患者进行回顾性调查,依据是否治愈分为治愈组(n=782)和治疗失败组(n=113),采用单因素比较分析和多因素Logistic回归来筛选可能影响治疗失败的危险因素。结果:肺结核患者治疗失败率为12.6%(113/895);多因素分析结果显示有合并症(OR=2.960)、有空洞(OR=4.102)、2个月末痰检阳性(OR=3.308)、不规则服药(OR=1.837)、耐药(OR=5.712)、未全程督导(OR=4.401)、未系统管理(OR=1.908),这些因素均为肺结核治疗失败的危险因素。结论:肺结核治疗失败率仍然较高,影响其治疗失败的独立危险因素包括伴随合并症、肺部有空洞、2个月末痰检阳性、不规则服药、耐药性、未全程督导及未系统化管理。
Objective: To investigate the risk factors of treatment failure in patients with pulmonary tuberculosis, and to provide the basis for improving the therapeutic effect. Methods: A total of 895 confirmed pulmonary tuberculosis patients were retrospectively analyzed. One-factor comparative analysis and multivariate Logistic regression were used to screen the possible influence depending on whether the cure was divided into cured group (n = 782) and failed treatment group (n = 113) Risk factors for treatment failure. Results: The failure rate of treatment in patients with pulmonary tuberculosis was 12.6% (113/895). Multivariate analysis showed that the patients had complications (OR = 2.960) Irregular medication (OR = 1.837), resistance (OR = 5.712), incomplete supervision (OR = 4.401), and no systematic management (OR = 1.908) were all risk factors for the failure of treatment for tuberculosis. CONCLUSIONS: The failure rate of treatment of pulmonary tuberculosis is still high, and the independent risk factors affecting the failure of treatment include concomitant comorbidities, empty lungs, positive sputum tests at the end of 2 months, irregular medication, drug resistance, incomplete supervision and unsystematic management.