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目的评价替加色罗治疗老年慢性功能性便秘的疗效和安全性。方法本试验通过38例老年慢性功能性便秘患者接受替加色罗治疗,疗程4周,观察排便次数和大便性状的变化。结果治疗2周和4周的总有效率分别为55.3%和60.5%;排便次数(次.周-1)分别由治疗前(1.48±0.61)增至(3.52±0.93)(2周)和(3.57±0.89)(4周),P<0.05;治疗2周和4周后患者大便性状正常例数由治疗前的0例增至17例和18例;治疗4周后患者的腹胀、腹痛、排便困难、食欲不振等四症状的缓解率均>60%。不良反应的发生率为5.3%,未见严重不良反应。结论替加色罗是一种治疗老年慢性功能性便秘有效、安全的药物。
Objective To evaluate the efficacy and safety of tegaserod in the treatment of senile chronic functional constipation. Methods In this study, 38 elderly patients with chronic functional constipation were treated with tegaserod for 4 weeks. The changes of defecation times and stool traits were observed. Results The total effective rates at 2 weeks and 4 weeks after treatment were 55.3% and 60.5%, respectively. The defecation times (week and week -1) were increased from 1.48 ± 0.61 to 3.52 ± 0.93 and 2 weeks respectively 3.57 ± 0.89) (4 weeks), P <0.05. After 2 weeks and 4 weeks of treatment, the normal number of stool patients increased from 0 cases before treatment to 17 cases and 18 cases. After 4 weeks of treatment, the patients had bloating, abdominal pain, Defecation difficulties, loss of appetite and other four symptoms were> 60%. The incidence of adverse reactions was 5.3%, no serious adverse reactions. Conclusion Tegaserod is an effective and safe drug for senile chronic functional constipation.