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目的 观察促性腺素释放激素类似物 (GnRH A)缓释亮丙瑞林治疗女童特发性中枢性性早熟的疗效。方法 以GnRH A缓释注射剂治疗 5例特发性中枢性性早熟女童 6个月。结果 治疗期间可见第二性征发育减退、月经被抑制、增高的血清E2 水平降到青春前期水平 ,生长速率减慢和骨过度成熟被抑制。治疗期间未见有明显不良反应。结论 GnRH A缓释注射剂对特发性中枢性性早熟有确切疗效。
Objective To observe the efficacy of gnrH A sustained release leuprorelin in the treatment of idiopathic central precocious puberty in girls. Methods Five patients with idiopathic central precocious puberty were treated with GnRH A sustained-release injection for 6 months. Results During the treatment period, the second sexual characteristics showed diminished development, menstruation was inhibited, elevated serum E2 level dropped to the level of pre-adolescence, slowed down the growth rate and excessive bone maturation was inhibited. No significant adverse reactions during treatment. Conclusion GnRH A sustained release injection has the exact effect on idiopathic central precocious puberty.