自从结核病的化疗广泛应用以来,抗结核药物导致肝损害已引起临床重视,尤其是近几年,常有利福平联合用药导致严重肝损害、黄疸、甚至急性肝细胞坏死而引起死亡的个案报告。为了指导临床合理、安全用药,通过肺结核化疗病人的肝功能动态改变的分析,探讨安全用药的一般规律,今将我所有关的部分住院病例总结如下: 资料 Since the widespread use of chemotherapy for tuberculosis, liver damage caused by anti-TB drugs has attracted clinical attention, especially in recent years, there are often reports of serious cases of liver damage, jaundice and even death caused by acute liver cell necrosis caused by the combination of rifampicin. In order to guide the clinical rational, safe medication, through the analysis of the dynamic changes of liver function in patients with pulmonary tuberculosis chemotherapy to explore the general rules of safe medication, now all of my relevant in-patient cases are summarized as follows: