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目的总结近2年潍坊医学院附属医院新生儿科血培养检出菌分布及耐药状况,以指导临床抗菌药物应用。方法选取我院1519例患儿(日龄≤28d)血培养分离出致病菌进行回顾总结及耐药分析。结果检出致病菌共276株(18.2%),分别含革兰阳性菌222株、革兰阴性菌45株及真菌9株;革兰阳性菌的首位检出菌为凝固酶阴性葡萄球菌(CNS),其次为金黄色葡萄球菌,对青霉素类、头孢类药物高水平耐药,未检出万古霉素耐药株(VRSA)及替考拉宁耐药株;革兰阴性菌前两位检出菌为肺炎克雷伯菌(KP)及大肠埃希菌(E.coli),对碳青霉烯类抗生素敏感,对常用抗生素耐药率高。结论我院新生儿科血培养以革兰阳性球菌检出为主,种类繁多且多重耐药,临床应及早送检血培养以指导治疗用药。
Objective To summarize the distribution and drug resistance of neonatal blood culture in Weifang Medical College Affiliated Hospital in recent 2 years to guide the clinical application of antibacterial drugs. Methods A total of 1519 children (day age ≤ 28 days) were selected from the blood culture to isolate pathogens and to review and analyze their resistance. Results A total of 276 pathogens (18.2%) were detected, including 222 strains of Gram-positive bacteria, 45 strains of Gram-negative bacteria and 9 strains of fungi. The first gram-positive bacteria were coagulase-negative staphylococci CNS), followed by Staphylococcus aureus, resistant to penicillins and cephalosporins, no vancomycin-resistant strains (VRSA) and teicoplanin-resistant strains were detected; the first two Gram-negative bacteria The test strains were Klebsiella pneumoniae (KP) and Escherichia coli (E.coli), which were sensitive to carbapenem antibiotics and had a high rate of resistance to commonly used antibiotics. Conclusion Neonatal blood culture in our hospital is mainly Gram-positive cocci. It has a wide range of multi-drug resistance and should be sent to blood culture clinically to guide the medication.