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氯喹目前仍广泛用于预防和治疗疟疾。为了有效的抑制红内期疟原虫,必须要达到足够的血浓度。本文介绍了在一次口服标准剂量氯喹的同时进食不同种类的早餐后所测得的血浆药物浓度的研究结果。8名27～40岁的健康志愿者为受试对象,每人每次给以标准剂量的硫酸氯喹(相当于氯喹碱基600mg)。服药后隔五周再进行另一次试验,共3次。每次药物剂量相同但条件不同。第一种为隔天晚上禁食,早晨服药后2小时内不进食。第二种为服药同时进高脂肪高蛋白早餐(白脱、咸肉、鸡蛋、面包、橙
Chloroquine is currently still widely used in the prevention and treatment of malaria. In order to effectively inhibit red-phase Plasmodium, we must achieve adequate blood concentration. This article describes the results of a study of plasma drug concentrations measured after oral administration of a standard dose of chloroquine simultaneously with different types of breakfast. Eight healthy volunteers aged 27-40 years were enrolled, each serving a standard dose of chloroquine sulfate (equivalent to chloroquine base 600 mg). After taking another five weeks interval another test, a total of 3 times. Each time the same dose of medicine but different conditions. The first one is fasting the next night, do not eat within 2 hours after taking the morning. The second is to take medication at the same time into the high-fat high-protein breakfast (white, bacon, eggs, bread, orange