多发性骨髓瘤是浆细胞异常增生的恶性肿瘤。由于增殖程度和浸润的部位不同,临床表现复杂多变,易误诊。其常见的临床表现包括骨痛、贫血、出血、肾功能不全等,淀粉样变亦是其继发性改变之一。欧美国家报告淀粉样变在多发性骨髓瘤的发生率为10%~15%,而我国的发生率为1.4%~5.6%[1] Multiple myeloma is a malignant tumor of abnormal proliferation of plasma cells. Due to the proliferation and infiltration of different parts of the clinical manifestations of complex and volatile, easily misdiagnosed. Its common clinical manifestations include bone pain, anemia, bleeding, renal insufficiency, amyloidosis is also one of its secondary changes. European and American countries report the incidence of amyloidosis in multiple myeloma was 10% to 15%, while the incidence in China was 1.4% to 5.6% [1]