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目的:最近的研究发现在克罗恩病患儿中存在骨矿物密度降低的现象。本次回顾性研究的目的是量化其发生率并寻找危险因素。研究对象和方法:采用双光子X 线吸收光谱仪测定了29例克罗恩病患儿的骨矿物密度。所有的儿童在随访期间都坚持服用钙剂和维生素D。结果:38%的儿童发生了骨质疏松症(Z分数≤-2.5 s),38%的儿童患有骨质减少(Z分数位于-1--2.5 s)。骨矿物密度降低与年龄相关,推测其降低可能始于青春期。骨质疏松症患儿的平均日皮质类固醇使用量明显增大。病情严重程度(用Harvey-Bradshaw指数评价)及免疫抑制剂的使用与骨矿物密度之间似有关联。性别、身高、病程和病变部位、营养等则与骨矿物密度无关。结论:本研究认为克罗恩病患儿骨矿物密度降低的发生率很高,主要是在青春期。类固醇激素的使用是一
PURPOSE: A recent study found a decrease in bone mineral density in children with Crohn’s disease. The purpose of this retrospective study is to quantify the incidence and look for risk factors. Subjects and Methods: Two-photon X-ray absorptiometry was used to determine bone mineral density in 29 Crohn’s children. All children insisted on taking calcium and vitamin D during follow-up. RESULTS: Osteoporosis occurred in 38% of children (Z score ≤-2.5 s) and in 38% of children with osteopenia (Z scores ranged from -1 to 2.5 s). Decreased bone mineral density is age-related, presumably its reduction may begin in adolescence. Osteoporosis in children with an average increase in the amount of corticosteroids. The severity of the disease (as assessed by the Harvey-Bradshaw index) and the use of immunosuppressive agents seem to correlate with bone mineral density. Sex, height, duration of disease and lesions, nutrition and bone mineral density has nothing to do. CONCLUSIONS: This study concluded that the incidence of bone mineral density de- creases in children with Crohn’s disease is high, predominantly in adolescence. The use of steroids is one