核转录因子NF-κB控制着一系列的细胞和组织过程,包括从细胞的分裂、增殖、凋亡到组织器官的各种应答活动。泛素-蛋白酶体系统通过以下3个途径影响NF-κB信号转导:①泛素-蛋白酶体降解NF-κB的抑制因子IκB;②对NF-κB前体如p105和p100进行加工并使之成熟;③通过非降解依赖机制激活IκB激酶IKK,从而抑制NF-κB。本文对泛素-蛋白酶体系统对NF-κB信号转导途径的影响进行综述。 Nuclear transcription factor NF-κB controls a series of cellular and tissue processes, including cell division, proliferation, apoptosis and various response activities of tissues and organs. The ubiquitin-proteasome system affects NF-κB signaling through three pathways: ① Ubiquitin-proteasome degrades the IκB inhibitor of NF-κB; ② processes NF-κB precursors such as p105 and p100 Mature; ③ IκB kinase IKK is activated by non-degradation-dependent mechanism and thus inhibits NF-κB. This article reviews the effects of the ubiquitin-proteasome system on the NF-κB signaling pathway.