为了解用Lens culinaris agglutinin reactiveAFP-L3联合传统的血清标记预测Down综合征的可靠性进行研究。 选择1989-1998年间530例正常妊娠妇女及有Down综合征胎儿孕妇31例,均因孕妇年龄大而作羊膜腔穿刺,根据胎儿核型异常血清及其他原因诊断为Down综合征者,于妊娠14-20周时取母血清。凡妊娠合并糖尿病、肝脏疾病、多胎妊娠及胎儿畸形者均除外。AEP—L3测定方法在2001年已有 To investigate the reliability of using Lens culinaris agglutinin reactiveAFP-L3 combined with traditional serum markers to predict Down syndrome. Select from 1989 to 1998, 530 cases of normal pregnant women and Down syndrome fetus 31 pregnant women, are pregnant because of large age for amniocentesis, according to fetal karyotype abnormal serum and other causes of Down syndrome were diagnosed in pregnancy 14 -20 weeks to take maternal serum. Where pregnancy with diabetes, liver disease, multiple pregnancy and fetal malformations were excluded. AEP-L3 determination method has been in 2001