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本文对38例内科保守治疗和15例经透析治疗由各种原因引起的尿毒症患者脂蛋白代谢进行了观察,并与284名年龄分布相近似的正常人血脂分析结果作对照,本组被测45例患者中,空腹三酸甘油酯(TG)浓度仅3例超过正常上限(130mg%),为6.7%,高TG血症的发生率明显低于其它作者所报导的结果,这可能与本组患者均采用饮食治疗有关。男女二组中最明显的脂蛋白异常是高密度脂蛋白胆固醇(HDL-C)降低(P<0.001),这种HDL-C降低似乎与透析无关。男女二组中尿毒患者的总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)与对照组(除女性组LDL-C外)相比亦有明显降低(分别为P<0.01和P<0.001),TC/HDL-C亦与对照组有显著差异(P<0.05)。尿毒症患者尤其是经透析治疗的患者中心血管并发症增高可能与他们在脂蛋白代谢中发生上述变化有密切关系。在男性组中TC.LDL-C及HDL-C与肌酐(Cr)呈显著负相关(P<0.05),但女性组却未发现这种关系。
In this paper, 38 cases of conservative treatment of internal medicine and 15 cases of dialysis treatment caused by various causes of uremia in patients with lipoprotein metabolism was observed and 284 age distribution similar to the normal blood lipids as control, the group measured Among the 45 patients, fasting triglyceride (TG) concentration was only 3 cases (6.7%) above the upper limit of normal (130 mg%) and the incidence of hypercholesteremia was significantly lower than those reported by other authors, Group patients were treated with diet. The most prominent abnormality of lipoproteins in both men and women in the two groups was a decrease in high-density lipoprotein cholesterol (HDL-C) (P <0.001). This reduction in HDL-C appeared to be unrelated to dialysis. The levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in both groups were also significantly lower than those in the control group (except LDL-C in women) (P <0.01 and P < 0.001), TC / HDL-C also had significant difference with the control group (P <0.05). Increased cardiovascular complications in patients with uremia, especially those treated with dialysis, may be closely linked to their changes in lipoprotein metabolism. There was a significant negative correlation between TC.LDL-C and HDL-C and creatinine (Cr) in males (P <0.05), but no such relationship was found in females.