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线状硬皮病(LS)是一种以皮肤受累为特征的病因不明的结缔组织病,临床上表现为线状分布的皮肤硬化和色素改变,其炎症和纤维变性过程可累及其下的皮下组织、肌肉、骨膜和骨,从而造成美容方面的问题,也可由于关节收缩无能及受损而导致功能障碍,偶尔可形成不可逆的畸形和毁容。最多见于生长期儿童,至今尚无满意的治疗方法。近来报道了骨化三醇
Linear scleroderma (LS) is an etiologic connective tissue disease characterized by involvement of the skin. It presents clinically as a linear distribution of skin sclerosis and pigmentary changes whose inflammatory and fibrotic processes can affect the underlying subcutaneous Tissue, muscle, periosteum, and bone, causing cosmetic problems. It can also cause dysfunction due to incompetent and impaired joint contractions, and occasionally irreversible deformity and disfigurement. Most seen in growing children, there is no satisfactory treatment. Calcitriol has recently been reported