论文部分内容阅读
目的:检测CD137L在喉癌中的表达,探讨其在喉癌发生和发展中的作用。方法:应用免疫组织化学染色法检测50例喉癌肿瘤组织和9例癌旁正常喉黏膜CD137L的表达。结果:CD137L在50例喉癌中阳性表达率为100%,而在9例癌旁正常喉黏膜组织中CD137L蛋白表达为阴性,与癌旁正常喉黏膜组织比较,喉癌CD137L阳性表达率明显增高,差异有统计学意义(P<0.01)。CD137L表达与患者年龄、性别和肿瘤生长部位无相关性,而与病理学分级、肿瘤T分期和有无淋巴结转移相关。结论:CD137L在喉癌组织的表达在喉癌发展过程中发挥重要作用。
Objective: To detect the expression of CD137L in laryngeal carcinoma and to explore the role of CD137L in the occurrence and development of laryngeal carcinoma. Methods: Immunohistochemical staining was used to detect the expression of CD137L in 50 cases of laryngeal carcinoma and 9 cases of adjacent normal laryngeal mucosa. Results: The positive rate of CD137L in 50 cases of laryngeal carcinoma was 100%, while the expression of CD137L in 9 cases of normal laryngeal mucosa was negative. Compared with normal laryngeal mucosa, the positive rate of CD137L in laryngeal carcinoma was significantly higher , The difference was statistically significant (P <0.01). There was no correlation between the expression of CD137L and the patient’s age, sex and tumor site, but related to the pathological grade, tumor T stage and lymph node metastasis. Conclusion: The expression of CD137L in laryngeal carcinoma plays an important role in the development of laryngeal carcinoma.