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H_2受体拮抗剂甲氰咪胍(C)和甲硝呋胍(R)治疗消化性溃疡有效。曾有报道,应用C治疗一个月后,可使高密度脂蛋白(HDL)—胆固醇水平增高,同样也增加Ⅲ型高脂蛋白血症妇女的HDL—胆固醇浓度。本文研究两药对血浆脂蛋白水平的影响,以确定上述影响是否由于H_2受体阻断作用所致。将24名年龄在24～36岁的健康受试者分两组,分别接受C和R治疗。12名(男6、女6)给予R,一天二次,一次150mg;12名(男6、女6)给予C,一天二次,一次400mg,共服四周。受试者在
H 2 receptor antagonists cimetidine (C) and ganutudine (R) in the treatment of peptic ulcer effectively. It has been reported that one month after treatment with C, high HDL-cholesterol levels are also increased, as are HDL-cholesterol levels in women with type III hyperlipoproteinemia. This article studies the effects of two drugs on plasma lipoprotein levels to determine whether these effects are due to H 2 receptor blockade. Twenty-four healthy subjects aged 24-36 years were divided into two groups and received C and R respectively. Twelve (male 6, female 6) were given R twice a day for 150 mg once; 12 (male 6, female 6) were given C twice a day for 400 mg for a total of four weeks. Subjects at