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目的探讨副伤寒甲肝损害的发生率、临床特点、治疗及预后。方法对 4 0 2例副伤寒甲患者的临床资料进行回顾性分析。结果 4 0 2例副伤寒甲患者中有肝损害 2 6 3例 (6 5 .4 % ) ,其中 72 .6 %无明显消化道症状 ,主要表现为转氨酶轻度到中度升高 ,少数有TBIL轻度升高 ;经抗炎、护肝治疗后肝功能均在 1个月内恢复正常 ;合并HBV的感染率为13.6 % ,重叠感染组与单纯感染组在肝损害程度及预后无明显差别。结论副伤寒甲肝损害发生率高 ,临床表现无特异性 ,容易误诊和漏诊 ;肝损害普遍较轻者其预后良好。治疗以抗炎为主 ,可在抗炎的同时加用护肝药治疗。
Objective To investigate the incidence of paratyphoid fever, clinical features, treatment and prognosis. Methods The clinical data of 420 cases of paratyphoid fever were retrospectively analyzed. Results There were 263 cases (65.4%) of the 41 cases with paratyphoid fever, of which 72.6% had no obvious gastrointestinal symptoms. The main manifestations were mild to moderate elevated aminotransferases, few TBIL mildly increased; the liver function returned to normal within 1 month after anti-inflammatory and hepatoprotective therapy; the infection rate of combined HBV was 13.6%; there was no significant difference in the degree of liver damage and prognosis between overlapping infection group and simple infection group . Conclusion The incidence of paratyphoid fever is high, the clinical manifestations are nonspecific, it is easy to misdiagnosis and misdiagnosis. The liver damage is generally mild with good prognosis. Anti-inflammatory treatment of the main anti-inflammatory can be added at the same time with liver medicine treatment.