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1996年Censini等[1] 在cagA阳性的幽门螺杆菌 (Hp)中发现一新的、与致病相关的基因群 ,称之为cag致病岛 (cagPathogenicityisland) ,因其编码蛋白与其它细菌编码的Ⅲ型、Ⅳ型分泌系统相关蛋白存在高度的同源性 ,即被推测功能为参与毒素
In 1996, Censini et al [1] found a new pathogenic related gene cluster in cagA-positive Helicobacter pylori (Hp), which is called cagPathogenicity island. Because of its coding protein and other bacterial coding Of type Ⅲ, type Ⅳ secretion system related proteins there is a high degree of homology, that is speculated to be involved in the role of toxins