论文部分内容阅读
目的:观察放射增敏剂希美钠(CM N a)配合放疗治疗肺癌的疗效及放射反应的变化。方法:将80例肿瘤患者随机分为增敏组和常规放疗组。常规放疗组40例(对照组),常规外照射总量DT 60~70G y/6~7周,每次2G y,每周5次,均采用6M VX线照射。增敏组40例,外照射合并甘氨双唑钠,外照射同常规放疗组,甘氨双唑钠的给药方案:生理盐水1 0 0mL+CM N a1.0g静脉滴注,每周3次。结果:完全缓解率增敏组和对照组分别为8 7.5%和6 5.0%(P<0.05),差异有显著性。达到完全缓解和部分缓解增敏组所用放射剂量明显少于对照组。增敏组放疗期间血常规、心电图、肝肾功能等同对照组,无异常改变。放射不良反应两组差异无显著性。结论:放疗合并甘氨双唑钠疗效优于单纯放疗,并可减少了放射剂量;放射不良反应无明显增加。
Objective: To observe the curative effect and radiation response of radiosensitizer Ximei Na (CM N a) combined with radiotherapy in the treatment of lung cancer. Methods: 80 patients with cancer were randomly divided into sensitized group and conventional radiotherapy group. Conventional radiotherapy group 40 cases (control group), conventional external beam total DT 60 ~ 70Gy / 6 ~ 7 weeks, each 2Gy, 5 times a week, using 6M VX line irradiation. Sensitization group, 40 cases of external irradiation combined with glycopyrrolate sodium, external radiation with conventional radiotherapy group, glycopyrrolate sodium dosing regimen: saline 1 0 0mL + CM N a1.0g intravenous infusion of 3 Times. Results: The complete remission rate in sensitized group and control group was 8 7.5% and 6 5.0% respectively (P <0.05), the difference was significant. The dose of radiation used to achieve complete remission and partial remission was significantly less than that of the control group. Sensitized group during radiotherapy blood, ECG, liver and kidney function equivalent to the control group, no abnormal changes. There was no significant difference in adverse reactions between the two groups. Conclusion: Radiotherapy combined with glycopyrrolate sodium is superior to radiotherapy alone and can reduce the radiation dose; no significant increase in adverse reactions.