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应用脉冲多普勒评价一次口服硫氮(艹卓)酮90mg对心肌梗塞患者左室舒张和充盈动力学的急性效应。结果表明,服药后左室舒张早期最大流速、E/A比值、快速充盈分数和快速充盈减速度分别增加10.8%±3.3%(P<0.01),20%±6.5%(P<0.O1),17%±4.8%(P<0.001)和19.8%±9.9%(P<0.01),等容舒张期缩短10.4%±4.7%(P<0.001)。提示心肌梗塞后左室舒张和充盈功能失常在一定程度上是可逆的,硫氮(艹卓)酮能有效地改善心肌梗塞患者的左室舒张和充盈功能。
Pulmonary Doppler echocardiography was used to assess the acute effect of oral administration of 90 mg oral thiadiazole on left ventricular diastolic and filling kinetics in patients with myocardial infarction. The results showed that the maximal rate of left ventricular diastolic velocity, E / A ratio, fast filling fraction and rapid filling deceleration were increased by 10.8% ± 3.3% (P <0.01) and 20% ± 6.5% (P <0.01) , 17% ± 4.8% (P <0.001) and 19.8% ± 9.9% (P <0.01), and the isovolumic diastolic shortening by 10.4% ± 4.7% (P <0.001). Suggesting that left ventricular diastolic and filling dysfunction after myocardial infarction to a certain extent, is reversible, sulfur nitrogen (艹 Zhuo) ketone can effectively improve left ventricular diastolic and filling function in patients with myocardial infarction.