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目的:研究血清ICA、GAD抗体检测对2型糖尿病病人中成人缓慢进展性自身免疫性糖尿病(LADA)的诊断价值。方法:采用酶联免疫法测定219例2型糖尿病人血清ICA、GAD抗体,体重指数,血糖,胰岛素(INS),C-肽(C-P)分泌水平并进行比较。结果:ICA、GAD抗体阳性率为33%。阳性病例与阴性病例在年龄、性别、体重指数、血糖及INS、C-P分泌水平(曲线下面积)的比较均无显著性差异(P>0.05)。结论:(1)2型糖尿病人中LADA病人可能占比例较高。(2)LADA病人缺乏特征性临床表现,ICA、GAD抗体检测在其早期诊断中有重要意义。
Objective: To investigate the diagnostic value of serum ICA and GAD antibody in the diagnosis of slow-progressing autoimmune diabetes mellitus (LADA) in type 2 diabetes mellitus. Methods: Serum ICA, GAD antibody, body mass index, blood glucose, insulin (INS) and C-peptide secretion of 219 type 2 diabetic patients were detected by enzyme-linked immunosorbent assay and compared. Results: The positive rate of ICA and GAD antibody was 33%. There was no significant difference in age, sex, body mass index, blood glucose, INS and C-P secretion (area under the curve) between positive and negative cases (P> 0.05). Conclusion: (1) LADA patients in type 2 diabetes may account for a higher proportion. (2) LADA patients lack of characteristic clinical manifestations, ICA, GAD antibody test in its early diagnosis of great significance.