Graves病(GD)是一种自身免疫性疾病,临床表现为多系统损害,自身免疫监护缺陷可能是发病的主要原因,具有明显的遗传倾向。调查显示,同卵双生子中如果有1人患GD,则另1人患CD的机率可高达30%～60%,而异卵双生子患同样疾病的机率只有3%～9%[1]。 80年代中期以后,GD的研究进入分子病 Graves disease (GD) is an autoimmune disease, clinical manifestations of multiple system damage, autoimmune guardianship defects may be the main cause of the disease, with a clear genetic predisposition. According to the survey, if one of the identical twins has GD, the other one has a 30% to 60% chance of developing CD, while the chance of the same disease occurring in a fraternal twins is only 3% to 9% [1] . After the mid-1980s, GD’s research into molecular disease