急性肾损伤（AKI）是一种临床常见的急危重症，缺血性肾损伤是其主要类型。缺血性肾损伤病死率高，临床主要以对症及支持治疗为主，缺乏有效的治疗措施。建立可靠的缺血性AKI动物模型是开展生理病理及药理学等研究的重要前提，进而探索有效的防治方法和策略。近年来，缺血性AKI动物模型的建立方法不断完善，本文对目前建立缺血性AKI动物模型的常用方法及模型特点进行归纳总结，以期为研究者合理选择制模方法提供参考。“,”Acute kidney injury (AKI) is a common clinical critical illness, and ischemic kidney injury is the main type. The mortality rate of ischemic kidney injury is high, because the efficacy of treatment is limited due to symptomatic and supportive treatment. Establishing a reliable animal model of ischemic AKI is an important prerequisite for conducting research on physiological, pathological and pharmacological researches, so as to explore effective prevention methods and strategies. In recent years, the establishment methods of animal models of ischemic AKI have been continuously improved. The article summarizes the common methods and model characteristics of animal models of ischemic AKI in order to provide a reference for researchers to choose a reasonable modeling method.