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目的：探讨河南省先天性甲低的发病率及治疗效果；方法：以非选择的新出生婴儿４１０００ 人为筛查对象。于出生７２ 小时，充分母乳后足跟采血，应用ＤＥＬＦＩＡ 法检测标本中ＴＳＨ 水平（ＴＳＨ≥２０μＩＵ／ｍｌ 为阳性） 。为了确诊，用放免法检测阳性病人血清中ＴＳＨ、Ｔ３ 、Ｔ４ 的水平，确诊的病人立即给予口服甲状腺素片治疗并定期进行体格发育和智力发育监测。结果：４１０００ 例新生儿中ＣＨ病人６ 例，发病率为１／６８３３ ，与我国其他地区的发病率相比偏低。病人经过早期治疗，体格发育和智力发育达到同龄健康儿童水平。结论：初步筛查的结果表明河南省ＣＨ 的发病率基本符合我国ＣＨ 总的发病情况。早期口服甲状腺素片可获满意的治疗效果。
Objective: To investigate the incidence of congenital hypothyroidism and its therapeutic effect in Henan province. Methods: 41000 non-selected newborn infants were screened. At 72 hours after birth, blood was collected from the heel of the full breast, and the level of TSH in the specimens was detected by the DELFIA assay (TSH≥20μIU / ml was positive). In order to confirm the diagnosis, the serum levels of TSH, T3 and T4 in positive patients were detected by radioimmunoassay. The diagnosed patients were treated with oral thyroxine tablets and regular physical development and mental development monitoring. Results: Among 41000 newborns, 6 were CH patients, the incidence was 1/6833, which was lower than the incidence in other areas in China. After early treatment of patients, physical development and mental development to achieve the same age healthy children’s level. Conclusion: The preliminary screening results show that the incidence of CH in Henan Province basically meets the overall incidence of CH in our country. Early oral thyroxine tablets can be satisfied with the treatment effect.