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目的:探讨十一味参芪胶囊内服和热敏灸法对结直肠癌术后(气血两虚证)化疗患者的疗效和对血清基质金属蛋白酶-2(MMP-2),血管内皮生长因子(VEGF)和环氧合酶2(COX_2)水平的影响。方法:将98例结直肠癌手术后患者,依据入院先后顺序随机按数字表法分为试验组和对照组各49例。对照组术后采用Cape OX化疗方案和西医常规护理。试验组在对照组治疗的基础上加用十一味参芪胶囊内服和热敏灸法,并给予饮食和情志护理指导。两组疗程均为12周。进行治疗前后气血两虚证评分;记录化疗所致不良反应;进行治疗前后生活质量评价;检测治疗前后T淋巴细胞亚群和NK细胞水平;检测治疗前后MMP-2,COX_2和VEGF水平。结果:试验组实体瘤疗效总有效率为97.8%,高于对照组的82.93%(P<0.05);试验组白细胞减少、血小板减少、胃肠道反应和肝肾功能损害等不良反应发生率均低于对照组(P<0.05);试验组生活质量量表中恶心呕吐、疼痛和疲劳评分低于对照组(P<0.01),躯体功能、角色功能、情绪功能、社会功能和认识功能评分均高于对照组(P<0.01);试验组CD3~+,CD4~+和NK细胞水高于对照(P<0.01),CD8~+水平均低于对照组(P<0.01);试验组血清MMP-2,VEGF和COX_2水平低于对照组(P<0.01);治疗后试验组气血两虚证评分低于对照组(P<0.01)。结论:十一味参芪胶囊内服和热敏灸辅助用于结肠癌术后化患者能起到改善症状,降低化疗副作用,提高生活质量和患者免疫功能,防治肿瘤转移,其近期疗效显著。
Objective: To investigate the effect of eleven flavor and shenqi capsule orally and heat-sensitive moxibustion on the patients with postoperative colorectal cancer (qi and blood deficiency syndrome) chemotherapy and the effect on serum matrix metalloproteinase-2 (MMP-2), vascular endothelial growth factor (VEGF) and cyclooxygenase 2 (COX_2) levels. Methods: 98 cases of colorectal cancer patients after surgery, according to the order of admission randomly according to digital table divided into experimental group and control group, 49 cases. The control group was treated with Cape OX chemotherapy and routine western medicine. The experimental group in the control group based on the treatment plus eleven flavor Shenqi capsule Oral and heat-sensitive moxibustion, and give diet and emotional guidance. The two groups were treated for 12 weeks. Before and after treatment, Qi and blood deficiency scores were scored. Adverse reactions caused by chemotherapy were recorded. Quality of life was evaluated before and after treatment. T lymphocyte subsets and NK cell levels were measured before and after treatment. MMP-2, COX 2 and VEGF levels were measured before and after treatment. Results: The total effective rate of solid tumor in experimental group was 97.8%, which was higher than that in control group (82.93%, P <0.05). The incidences of adverse reactions such as leukopenia, thrombocytopenia, gastrointestinal reaction, (P <0.05). The scores of nausea, vomiting, pain and fatigue in the test group were lower than those in the control group (P <0.01). The body function, role function, emotional function, social function and cognitive function score (P <0.01). The levels of CD3 +, CD4 + and NK cells in the experimental group were significantly higher than those in the control group (P <0.01), while the levels of CD8 + in the experimental group were lower than those in the control group The levels of MMP-2, VEGF and COX_2 in the experimental group were lower than those in the control group (P <0.01). After treatment, the deficiency of qi and blood in the experimental group was lower than that in the control group (P <0.01). Conclusion: The effects of eleven flavor and shenqi capsule orally and heat-sensitive moxibustion for postoperative colon cancer patients can improve the symptoms, reduce the side effects of chemotherapy, improve the quality of life and immune function of patients, and prevent tumor metastasis.