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对29名家族性高胆固醇血症患者和正常人的研究表明:前者红细胞膜ATP酶活性较后者显著降低,并且与血浆总胆固醇和低密度脂蛋白-胆固醇水平以及淋巴细胞LDL受体功能的降低呈高度负相关;Ca~(2+)-Mg~(2+)-ATP酶活性与血浆高密度脂蛋白-胆固醇水平呈正相关。这些变化的研究,对于进一步探讨动脉粥样硬化的发生机制及其防治可能具有重要意义。
29 familial hypercholesterolemic patients and normal subjects showed that: the former erythrocyte membrane ATPase activity was significantly lower than the latter, and with plasma total cholesterol and low density lipoprotein - cholesterol levels and lymphocyte LDL receptor function While the activity of Ca ~ (2 +) - Mg ~ (2 +) - ATPase was positively correlated with the level of plasma high density lipoprotein-cholesterol. These changes in the study for the further study of the pathogenesis of atherosclerosis and its prevention may be of great significance.