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目的 :观察平喘合剂对豚鼠引喘潜伏期及离体气管平滑肌的影响。方法 :采用喷雾致喘法建立豚鼠哮喘模型。采用气管螺旋条法 ,用磷酸组胺或乙酰胆碱使气管条收缩 ,描记用药前、后的收缩曲线。结果 :平喘合剂可明显延长引喘潜伏期。明显降低气管条的收缩幅度。结论 :平喘合剂有明显的平喘作用。其机理与平喘合剂具有明显松驰气管平滑肌的作用有关。
Objective : To observe the effect of Pingchuan Mixture on guinea pigs’ induced asthma latency and isolated tracheal smooth muscle. Methods: The asthma model of guinea pigs was established by spray-induced asthma. Using the tracheal spiral strip method, the tracheal strip was contracted with histamine phosphate or acetylcholine, and the contraction curve before and after the administration was traced. Results : Pingchuan Mixture can significantly prolong the latency of asthma. Significantly reduce the shrinkage of tracheal strips. Conclusion: Pingchuan Mixture has obvious asthma effect. Its mechanism is related to the role of Pingchuan Mixture in significantly relaxing tracheal smooth muscle.