磨牙症是一种白天或夜间发作的牙齿功能异常活动,表现为牙齿紧咬、磨动。在成年人群中发生率为5％～96％,至今其发病机制尚未清楚,也未找到最佳治疗方法。 肉毒杆菌毒素(botulinum toxin,BTX)是由厌氧的肉毒杆菌产生的安全有效的治疗各种神经紊乱的生物毒素。它可抑制神经肌连接处的乙酰胆碱释放,从而致局部肌肉放松。本研究旨在评价BTX对神经性紊乱伴发磨牙症患者的治疗效果。 对象和方法 18例患者(17例女性,1例男 Bruxism is an abnormal activity of the teeth during the daytime or nighttime attack, manifested as teeth biting, grinding. In the adult population incidence of 5% to 96%, so far the pathogenesis is not yet clear, but also did not find the best treatment. Botulinum toxin (BTX) is a safe and effective biotoxin produced by anaerobic botulinum to treat various neurological disorders. It inhibits the release of acetylcholine at the neuromuscular junction, causing local muscle relaxation. The aim of this study was to evaluate the therapeutic effect of BTX on patients with neurological disorders associated with bruxism. Subjects and methods 18 patients (17 women, 1 male