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目的 探讨局部浸润性膀胱癌患者的临床特征及预后影响因素,为提高临床诊治水平提供依据.方法 对153例局部浸润性膀胱癌患者的临床特征及随访资料进行回顾性分析,采用Cox比例风险回归模型探讨影响局部浸润性膀胱癌患者预后的相关因素.结果 本组患者中,89.5%表现为血尿,10.5%表现为膀胱刺激症状;随访生存时间为8个月-72个月,1 a、3 a、5 a生存率分别为75.8%、64.1%、46.4%;单因素分析显示:有无肾积水、T分期、有无淋巴结转移、肿瘤组织的分化程度对患者生存率有显著性影响(P<0.05或0.01);Cox多因素分析显示:肾积水、T分期、淋巴结转移是影响局部浸润性膀胱癌患者预后的独立危险因素(P<0.05或0.01).结论 局部浸润性膀胱癌患者主要临床表现为血尿、膀胱刺激征;肾积水、T分期、淋巴结转移是影响患者预后的独立危险因素.“,”Objective To explore the clinical features of patients with invasive bladder cancer (IBC) and factors influencing prognosis to provide basis for improving clinical diagnosis and treatment levels. Methods The clinical features and follow-up data of 153 IBC patients were retrospectively analyzed and factors influencing prognosis explored using Cox proportional hazard model. Results 89.54% of 153 patients showed hematuresis and 10.5% irritation sign of bladder;survival time were 8~72 months and the survival rates of 1,3 and 5 years respectively 75.8%,64.1% and 46.4%;single-factor analysis showed that whether they were with hydronephrosis,T staging,whether they had lymphaden metastasis and the differentiation degrees of tumor tissue had notable influences on patients survival rates (P<0.05 or 0.01);Cox multiple factor analysis showed that hydronephrosis,T staging and lymphaden metastasis were independent risk factors influencing the prognosis of IBC patients (P<0.05 or 0.01). Conclusion Hydronephrosis and irritation sign of bladder are main clinical manifestations of IBC patients;hydronephrosis,T staging and lymphaden metastasis are independent risk factors influencing the prognosis of IBC patients T staging and lymph gland were independent risk factor of prognosis.