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加《医学邮报》第16卷第16期(1980年)报道莫里斯(John Maurice)从布赖顿发出的消息:利莫格斯大学医学中心眼科的艾德尼斯(Jean-Paul Adenis)医生在这里召开的欧洲眼科学会大会上说,大剂量使用某些抗菌素可以引起角膜内皮细胞的严重损伤。将不同剂量的头孢金素和氨苄青霉素注入家兔眼前房或玻璃体3小时之后,在扫描电子显微镜下可见角膜内皮细胞出现损伤。但若将氨苄青霉素注入眼内,即使其剂量大至0.1毫升溶液中含10毫克,也没造成损伤。庆大霉素在0.4～0.8毫克/0.1毫升剂量时不会造成损伤,剂量为2～4
Plus Medical Journal, Vol. 16, No. 16 (1980) reports that John Maurice sent a message from Brighton: Dr Jean-Paul Adenis, from the Department of Ophthalmology at the University Medical Center at Lymegulls Speaking at the European ophthalmology conference here, large doses of certain antibiotics can cause severe damage to corneal endothelial cells. After different doses of ceftazidime and ampicillin were injected into the anterior chamber or vitreous of rabbits for 3 hours, corneal endothelial cells were observed under scanning electron microscope. However, if ampicillin is infused into the eye, it does not cause any damage even if it is contained in a quantity up to 0.1 ml and contains 10 mg in solution. Gentamycin at 0.4 ~ 0.8 mg / 0.1 ml dose will not cause damage to a dose of 2 to 4