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目的探讨ＴＮＦα、ＩＬ６在急性脑血管病发病中的作用。方法采用双抗体夹心ＥＬＩＳＡ法检测了４８例急性脑血管病患者血浆ＴＮＦα和ＩＬ６含量的动态变化。结果急性脑血管病发病第１ｄ、第３ｄ上述指标均高于对照组（Ｐ＜０．０１）。第７ｄ和第１４ｄ已趋于恢复，仅ＳＡＨ组在第７ｄ高于对照组（ＴＮＦα、ＩＬ６分别为Ｐ＜０．０５、Ｐ＜０．０１）。结论ＴＮＦα和ＩＬ６作为免疫因素参与了急性脑血管病的发生发展过程，提示ＴＮＦα和ＩＬ６拮抗剂将是今后防治脑血管病的一条新途径。
Objective To investigate the role of TNFα and IL6 in the pathogenesis of acute cerebrovascular disease. Methods The dynamic changes of plasma TNFα and IL6 levels in 48 patients with acute cerebrovascular disease were detected by double antibody sandwich ELISA. Results The incidence of acute cerebrovascular disease on the 1st day and the third day were higher than those in the control group (P <0.01). On the 7th and 14th days, the SAH group was higher than that of the control group only on the 7th day (P <0.05, P <0.01, respectively). Conclusion TNFα and IL6 are involved in the pathogenesis of acute cerebrovascular disease as an immunological factor, suggesting that TNFα and IL6 antagonists will be a new way to prevent and treat cerebrovascular diseases in the future.