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目的探讨血清神经元特异性烯醇化酶(NSE)及白细胞介素-6(IL-6)在难治性癫痫患儿中的表达水平及临床意义。方法回顾性分析我院神经外科2011年1月-2013年1月50例难治性癫痫患儿的临床资料。结果癫痫发作组患儿的血清NSE和IL-6均明显高于对照组和癫痫非发作组患儿,差异有统计学意义(P<0.05);癫痫非发作组和对照组患儿的血清NSE和IL-6水平之间无统计学差异(P>0.05)。结论难治性癫痫患儿血清NSE及IL-6的表达水平升高,可能会进一步加重炎性损伤,临床应给予充分重视。
Objective To investigate the expression of serum neuron specific enolase (NSE) and interleukin-6 (IL-6) in children with refractory epilepsy and its clinical significance. Methods The clinical data of 50 children with refractory epilepsy from January 2011 to January 2013 in our department of neurosurgery were retrospectively analyzed. Results Serum levels of NSE and IL-6 in seizure group were significantly higher than those in control group and epileptic non-seizure group (P <0.05). Serum levels of NSE in non-seizure group and control group And IL-6 levels between the no significant difference (P> 0.05). Conclusions Serum levels of NSE and IL-6 in children with refractory epilepsy may increase the inflammatory injury further and should be given sufficient attention in clinic.