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十二指肠溃疡的病理生理学近年来由于肠肽激素的研究,十二指肠溃疡的病理生理学也已形成新的概念。十二指肠溃疡的发病与十二指肠球部的高胃酸和高胃蛋白酶浓度有密切关系。造成十二指肠球部胃酸和胃蛋白酶浓度增高的原因如下:(1)胃酸的过度分泌;(2)胃排空速度的异常增加;(3)十二指肠内胃酸中和机制的缺陷。研究证明,胃肠道的分泌和运动功能受神经、内分泌和旁分泌三重系统的控制和调节。关于胃肠道功能的神经控制学说,即巴甫洛夫的神经控制理论
Pathophysiology of duodenal ulcer In recent years due to the study of gut peptide hormones, the pathophysiology of duodenal ulcer has also formed a new concept. The incidence of duodenal ulcer and duodenal bulb of high gastric acid and high pepsin concentration are closely related. The causes of increased gastric acid and pepsin concentrations in the duodenal bulb are as follows: (1) hypersecretion of gastric acid; (2) abnormal increase of gastric emptying rate; (3) defects of gastric intraepithelial acid-neutralizing mechanism in the duodenum . Studies have shown that gastrointestinal secretion and motor function by the nervous, endocrine and paracrine triple control and regulation system. The neural control theory of gastrointestinal function, Pavlov’s theory of neural control