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解放军总医院自 1997年开展内镜下注射A型肉毒毒素治疗贲门失弛缓以来 ,至今治疗病人共 165例。治疗前后病人食管下段括约肌 (LES)压力 ( 41 76± 2 2 0 0比 19 14± 11 40mmHg)和LES松弛压力( 14 74±9 41比 8 5 1± 7 85mmHg)差异显著 (P <0 0 0 1)。治疗后随访 12、2 4、3 6个月 ,分别有 87% ( 111/ 12 7)、84% ( 70 / 83 )和 71% ( 2 9/ 41)病人症状未复发。本文总结了 5年应用此技术的经验 ,对提高疗效和推广应用很有一定意义
People’s Liberation Army General Hospital since 1997 to carry out endoscopic injection of botulinum toxin type A treatment of cardiac achalasia since treatment of patients a total of 165 cases. Before and after treatment, the lower esophageal sphincter pressure (41 76 ± 2 20 0 vs 19 14 ± 11 40mmHg) and LES relaxation pressure (14 74 ± 9 41 vs 851 ± 7 85mmHg) were significantly different (P 0 00 0 1). After treatment for 12, 24, 36 months, 87% (111/127), 84% (70/83) and 71% (29/41) of the patients did not relapse. This article summarizes the five years of experience in the application of this technology to improve the efficacy and promote the use of a lot of sense