女性,48岁。于1970年以后反复发作畏寒、发热,多为不规则热型,有时呈间歇热,伴有出汗。膝、踝关节及四肢肌肉疼痛。偶于发热期间四肢出现散在黄豆大小之红色皮下结节,有压痛,数天后自行消退。1979年症状加重,发病频繁。面部及下肢水肿,头痛,血压稍高。曾在多个医院住院治疗。先后诊断为风湿热、疟疾、败血症、慢性肾炎等数种疾病。经抗生素、强的松和对症治疗,症状可短暂缓解。1980年2月14日复发,体温达38～40℃,小腿肌肉、关节疼痛,踝部水肿,尿少。用红霉素 Female, 48 years old. In 1970 after repeated episodes of chills, fever, mostly irregular heat type, and sometimes intermittent fever, accompanied by sweating. Knee, ankle and limb muscle pain. Occasionally during the fever appeared in the size of the scattered red bean subcutaneous nodules, tenderness, self-subsided after a few days. Symptoms increased in 1979, the incidence of frequent. Facial and lower extremity edema, headache, blood pressure slightly higher. He has been hospitalized in several hospitals. Has diagnosed as rheumatic fever, malaria, sepsis, chronic nephritis and other diseases. After antibiotics, prednisone and symptomatic treatment, symptoms can be temporarily alleviated. February 14, 1980 relapse, body temperature of 38 ~ 40 ℃, calf muscles, joint pain, ankle edema, oliguria. With erythromycin