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产前糖皮质激素（antenatal corticosteroid, ACS）在临床中的应用已近半个世纪。研究显示，ACS能明显降低单胎中早产相关并发症（如新生儿呼吸窘迫综合征等）的发生率。基于ACS在单胎中的显著效果，国际指南建议可按照单胎常规处理流程进行双胎的治疗。然而目前关于ACS对双胎NRDS预防效果的研究结论不一。本文综述了ACS预防双胎NRDS效果的研究进展，以指导临床实践及进一步的研究工作。“,”Antenatal corticosteroids (ACS) have been used clinically for more than half a century. They effectively reduce the incidence of preterm-related complications, such as neonatal respiratory distress syndrome (NRDS). Based on the significant beneficial effect in singleton pregnancies, several international guidelines recommend that ACS for twin pregnancies refer to their singleton pregnancies protocol. However, the prevention effect of ACS on NRDS in twin pregnancy is inconsistent. This review summarizes the effects of ACS on the prevention of NRDS in twin pregnancy to provide a reference for clinical management and further study.