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正常肝细胞合成的胆酸,经过肝肠循环后仅有1％进入周围循环,因此,在正常人血清中的胆酸浓度很低。当肝胆系统发生病变时,将引起胆酸的肝肠循环紊乱,使血清中胆酸的浓度异常升高。但是,长期以来,由于不能用一般化学方法检测其浓度,所以,血清胆酸浓度的变化与肝胆之间的关系未能详细研究。近年来由于甘氨胆酸、硫石甘氨胆酸等胃肠道非激素类物质的RIA法发展和应用,这是胆酸测定方法学上的突破。应用RIA法测定血清结合胆酸(SCG),是一项比常规肝功能检查还要灵敏的指标,对于慢性肝炎复
Cholic acid, which is synthesized by normal liver cells, circulates around the intestine only after 1% of the enterohepatic circulation. Therefore, the cholic acid concentration in normal human serum is very low. When the liver and gallbladder system lesions occur, it will cause cholic acid and intestinal disorders, so that serum cholic acid concentration abnormalities. However, since the concentration can not be detected by a general chemical method for a long time, the relationship between changes in serum bile acid concentration and hepatobiliary behavior has not been studied in detail. In recent years, due to the development and application of RIA method of gastrointestinal non-hormonal substances such as glycocholic acid and thioglycolic acid, this is a breakthrough in the method of bile acid determination. RIA determination of serum combined with cholic acid (SCG), is a more sensitive indicator of liver function tests, for chronic hepatitis complex