根据过去对三氟氯乙烯的毒理研究认为其对肾脏损害最明显。因此,本实验是从大鼠肾脏方面寻找关于三氟氯乙烯慢性中毒的指标,以便能为临床早期发现慢性中毒患者提供线索,现作如下介绍。 材料和方法 实验样品为三氟氯乙烯精单体,纯度98％以上。染毒方式为动式吸入染毒,分高、低两个浓度组及对照组。高浓度组的三氟氯乙烯为1097～1240mg/m~3,低浓度组为491～539 mg/m~3。实验动物用雄性大白鼠,体重102～135 Based on past toxicological studies of chlorotrifluoroethylene that its most obvious damage to the kidneys. Therefore, this experiment is looking for indicators of chronic poisoning of chlorotrifluorocarbons in rat kidneys in order to provide clues for the early detection of chronic poisoning patients, as follows. Materials and methods Experimental samples for the chlorotrifluoroethylene monomer, purity of 98% or more. The way of exposure was dynamic inhalation and exposure, two high and low concentration groups and the control group. The chlorotrifluoroethylene in the high concentration group was 1097-1240 mg / m 3, while the low concentration group was 491-539 mg / m 3. Experimental animals male rats, weighing 102 to 135