论文部分内容阅读
目的:耐药、再感染是幽门螺杆菌感染治疗失败常见原因,通过与奥美拉唑三联疗法的比较,观察由雷贝拉唑胶囊主导的阶梯疗法对顽固性幽门螺杆菌感染治疗失败后幽门螺杆菌(HP)的根除率。方法:将200例HP阳性治疗失败的患者随机分为二组。A组(阶梯疗法组)105例,以雷贝拉唑胶囊20mg,每日1次,胶体酒石酸铋胶囊165mg,一天三次,克拉霉素胶囊0.5,每日2次和羟氨苄青霉素1000 mg,每日2次,连服三天后停克拉霉素、羟氨苄青霉素,改左氧氟沙星胶囊0.2,一天二次,奥硝唑分散片0.5一天二次,连服四天,总治疗一周;B组95例,以奥美拉唑胶囊20 mg,每日2次,羟氨苄青霉素1000 mg,每日2次,克拉霉素胶囊500 mg,每日2次,治疗一周为对照组。在治疗前和疗程结束4周以上,采用C14呼气试验检测HP。结果:A组的HP根除率为96.2%,明显高于B组的82.1%(P<0.01)。A、B两组副反应小,均能耐受。结论:阶梯疗法组HP根除率高、安全、耐受性好,不良反应少,是一种理想的HP治疗失败的补救治疗方案。
OBJECTIVE: Drug resistance and re-infection are common causes of failure in the treatment of Helicobacter pylori infection. By comparing triple therapy with omeprazole, we observed the pyloric etiology of failure of refractory Helicobacter pylori infection by step-therapy led by rabeprazole capsules Helicobacter (HP) eradication rate. Methods: 200 patients with failed HP positive treatment were randomly divided into two groups. A group (ladder therapy group) 105 cases, rabeprazole capsules 20mg, 1 day, colloidal bismuth tartrate capsules 165mg, three times a day, clarithromycin capsules 0.5, twice daily and amoxicillin 1000mg, each Day 2, and even served three days after stopping clarithromycin, amoxicillin, levofloxacin capsule 0.2, twice a day, ornidazole dispersible tablets 0.5 twice a day for four days, the total treatment for one week; B group of 95 cases, Omeprazole capsules 20 mg twice daily amoxicillin 1000 mg twice daily clarithromycin capsules 500 mg twice a day for one week as the control group. Before treatment and the end of treatment over 4 weeks, using C14 breath test to detect HP. Results: The eradication rate of HP in group A was 96.2%, which was significantly higher than that in group B (82.1%, P <0.01). A, B two side effects of small, can tolerate. Conclusion: The ladder therapy group HP eradication rate is high, safe, well tolerated, fewer adverse reactions, is an ideal remedy for HP failure treatment.